Prof. Dr.med. Ernst Niggli

Curriculum vitae

Education and professional experience

1974-1980	Medical studies, University of Bern.
1981-1982	Research Associate at the Institute for Biomedical Engineering, Federal Institute of Technology (ETH) and University of Zurich (Prof. Dr. F. H. Walz).
1983	Resident at the Department of Internal Medicine, Hospital of Sumiswald / Bern (Dr. M. Fey).
1984	Research Associate at the Institute for Biomedical Engineering, Federal Institute of Technology (ETH) and University of Zurich (Prof. Dr. F. H. Walz).
1985-1988	Research Associate at the Department of Physiology, University of Bern (Profs. S. Weidmann and R. Weingart).
1988-1989	Research Assistant Professor at the Department of Physiology, University of Maryland UMAB (Prof. Dr. W. J. Lederer).
1990	Research Assistant Professor at the Department of Physiology, Medical Biotechnology Center UMBI (Prof. Dr. W. J. Lederer).
1990-1995	Assistant Professor (Oberassistent) at the Department of Physiology, University of Bern. Cellular regulatory mechanisms in cardiac contraction and relaxation: role of the Na/Ca exchanger.
1996-2000	Associate Professor at the Department of Physiology, University of Bern.
2000	Visiting Professor, Department of Physiology, Loyola University, Maywood IL, USA.
2000-present	Professor (a.o.P.) at the Department of Physiology, University of Bern.
2007	Visiting Professor, Department of Pharmacology and Physiology, UMDNJ, Newark, NJ, USA.

Teaching Experience

1990 - 1994	Lectures for pharmacy students: cardiovascular physiology
1990 - present	Practical courses for medical students
1995 - 1997	Lectures for medical students: renal Physiology, energy metabolism and temperature regulation
1997 - present	Lectures for students of veterinary medicine and pharmacy: cardiovascular physiology
1999 - 2008	Coordinator, lecturer and tutor of the renal PBL course for medical students and dentists. Tutor of the PBL course "Metabolism".
2009 - today	Coordinator, lecturer and tutor of the cardiovascular and respiration PBL course for medical students and dentists.

Editorial boards, boards, honors

1994	Pfiizer prize in basic cardiology
2000-20007	Reviewing Editor The Journal of Physiology (London)
2007 - today	Editor Journal of Molecular and Cellular Cardiology
2004 - today	Member of the Science Council of the Swiss National Science Foundation
2008 - 2010	President of the Swiss Society of Physiology

Memberships in Professional Organizations

1986-today	Swiss Physiological Society
1988-today	Biophysical Society
2000-today	Physiological Society (U.K.)

Publications

sorted by year and first author

J. Ogrodnik, E. Niggli. Increased Ca2+ leak and spatiotemporal coherence of Ca2+ release in cardiomyocytes during β-adrenergic stimulation. J. Physiol. (Lond). 588.1:225-242, 2010 DOI

M. Fanchaouy, E. Polakova, C. Jung, J. Ogrodnik, N. Shirokova, E. Niggli. Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes. Cell Calcium 46:114-121, 2009 (Elsevier) DOI

K. Gusev, A.A. Domenighetti, L.M.D. Delbridge, T. Pedrazzini, E. Niggli, M. Egger. Angiotensin II mediated adaptive and maladaptive remodeling of cardiomyocyte excitation contraction coupling. Circ. Res. 105:42-50, 2009 DOI

E. Niggli. How to shut down Ca2+-induced Ca2+ release?. J. Physiol. (Lond). 587.21:5003-5004, 2009 DOI

V.M. Shkryl, A.S. Martins, N.D. Ullrich, M.C. Nowycky, E. Niggli, N. Shirokova. Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch. 458:915-928, 2009 DOI

M. Sztretye, J. Almassy, T. Deli, P. Szentesi, C. Jung, B. Dienes, C.A. Simut, E. Niggli, I. Jona, L. Csernoch. Altered sarcoplasmic reticulum calcium transport in the presence of the heavymetal chelator TPEN. Cell Calcium 46:347-355, 2009 (Elsevier) DOI

N.D. Ullrich, M. Fanchaouy, K. Gusev, N. Shirokova, E. Niggli. Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes. AJP Heart Physiol 297:H1992-H2003, 2009 DOI

K. Gusev, E. Niggli. Modulation of the local SR Ca2+ release by intracellular Mg2+ in cardiac myocytes. J. Gen. Physiol. 132:721-730, 2008 DOI

C. Jung, Martins A.S, Niggli E, Shirokova N. Dystrophic cardiomyopathy: amplification of cellular damage by Ca2+ signalling and reactive oxygen species-generating pathways. Cardiovasc. Res. 77:766-773, 2008

N. Shirokova, E. Niggli. Studies of RyR function in situ. Methods-Elsevier 46:183-193, 2008 (Elsevier) DOI

C. Jung, A.V. Zima, P. Szentesi, I. Jona, L.A. Blatter, E. Niggli. Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes. Cell Calcium 41:187-194 , 2007

M. Keller, C. Pignier, M. Egger, E. Niggli. F90927: A new member in the class of cardiactive steroids. Cardiovasc Drug Rev 25:210-220 , 2007

M. Keller, J.P.Y. Kao, M. Egger, E. Niggli. Calcium waves driven by "sensitization" wave-fronts. Cardiovasc. Res. 74:39-45 , 2007

E. Niggli. The cardiac sarcoplasmic reticulum filled with Ca2+and surprises. Circ. Res. 100:5-6, 2007

E. Niggli, N. Shirokova. A guide to sparkology: The taxonomy of elementary cellular Ca2+ signaling events. Cell Calcium 42:379-387 , 2007 DOI

S Kantevari, C J Hoang, J Ogrodnik, M Egger, E Niggli, G C R Ellis-Davies. Synthesis and two-photon photolysis of 6-(ortho-Nitroveratryl)-caged IP3 in living cells. Chembiochem 7:174-180, 2006

M. Keller, C Pignier, M Santelli, B Vacher, E Niggli, M Egger. Agonist specific L-type Ca2+-current stimulation in ventricular myocytes by a novel steroid-like compound. Cell Calcium 39: 425-433, 2006

A.G. Kléber, E. Niggli, J.A.S. McGuigan, R. Weingart. The early years of cellular cardiac electrophysiology and Silvio Weidmann (1921-2005). Heart Rhythm 3(3):353-9, 2006

A Momotake, N Lindegger, E Niggli, R J Barsotti, G C R Ellis-Davies. The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods 3:35-40, 2006

E. Niggli, A G Kléber, R Weingart. Founder of cardiac cellular electrophysiology: Honouring Silvio Weidmann, 7 April 1921-11 July 2005. J. Physiol. (Lond). 570:431-432, 2006

C Pignier, M Keller, B. Vié, B Vacher, M Santelli, E Niggli, M Egger, B Le Grand. A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle. Br. J. Pharmacol. 147:772-782, 2006

M. Egger, H. Porzig, E. Niggli, B. Schwaller.. Rapid turnover of the "functional" Na+-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach. Cell Calcium 37:233-243, 2005

N. Lindegger, E. Niggli. Paradoxical SR Ca2+ release in guinea pig cardiac myocytes after ß-adrenergic stimulation revealed by two-photon photolysis of cated Ca2+. J. Physiol. (Lond). 565.3: 801-813, 2005

T.R. Shannon, D.M. Bers, L.A. Blatter, E. Niggli. Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium 38: 497-505, 2005

M. Keller, C. Pignier, E. Niggli, M. Egger. Mechanisms of Na-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement. J. Membr. Biol. 198:159-175 , 2004

E. Niggli, M. Egger. Applications of multi-photon microscopy in cell physiology. Front. Biosci. 9: 1598-1610, 2004

P. Szentesi, C. Pignier, M. Egger, E.G. Kranias, E. Niggli. Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circ. Res. 95:807-813 , 2004

H. Zhang, D. Noble, M. Cannell, C. Orchard, M. Lancaster, M.R. Boyett, A.V. Holden, M. Saleet Jafri, E.A. Sobie, W.J. Lederer, S.S. Demir, A. Michailova, F. DelPrincipe, M. Egger, E. Niggli, G.L. Smith, C.M. Loughrey, N. MacQuaide. J. Dempster, A.T. Trafford. Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. IJBC 13:3535-3560 , 2003

P. Darbon, C. Pignier, E. Niggli, J. Streit. Involvement of calcium in rhythmic activity induced by disinhibition in cultured spinal cord networks. J. Neurophysiol. 88:1461-1468, 2002

A.M. Gómez, B. Schwaller, H. Porzig, G. Vassort, E. Niggli, M. Egger. Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Circ. Res. 91:323-330, 2002

P Lipp, M Egger, E Niggli. Spatial characteristics of sarcoplasmic reticulum Ca2+release events triggered by L-type Ca2+ current and Na+ current in guinea-pig cardiac myocytes. J. Physiol. (Lond). 542.2:383-393, 2002

A. Michailova, F. DelPrincipe, M. Egger, E. Niggli. Spatiotemporal features of Ca2+ buffering and diffusion in atrial cardiac myocytes with inhibited sarcoplasmic reticulum. Biophys. J. 83:3134:3151, 2002

E. Niggli, M. Egger. Calcium quarks. Front. Biosci. 7:d1288-1297, 2002

F. DelPrincipe, M. Egger, E. Niggli. L-type Ca2+ current as the predominant pathway of Ca2+ entry during INa activation in β-stimulated cardiac myocytes. J. Physiol. (Lond). 527.3:455-466, 2000

M. Egger, E. Niggli. Paradoxical block of the Na+ - Ca2+ exchanger by extracellular protons in guinea-pig ventricular myocytes. J. Physiol. (Lond). 523:353-366, 2000

B. Schwaller, M. Egger, P. Lipp, E. Niggli. Application of antisense oligodeoxynucleotides for suppression of Na+ / Ca2+ exchange. Methods Enzymol. 314:454-476, 2000

Abstracts

sorted by year and first author

M. Fanchaouy, C. Jung, E. Polakova, J. Ogrodnik, N. Shirokova, E. Niggli. Abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes: involved pathways. Gordon Research Conference "Cardiac Regulatory Mechanisms”, New London, NH, USA. 2008

M. Fanchaouy, C. Jung, J. Ogrodnik, E. Polakova, N. Shirokova, E. Niggli. Abnormal stress-induced Ca2+ influx into dystrophic MDX cardiomyocytes: involved pathways. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. 2008

M. Fanchaouy, C. Jung, J. Ogrodnik, E. Polakova, N. Shirokova, E. Niggli, M. Egger. Pathways of abnormal stress-induced calcium influx into dystrophic mdx cardiomyocytes. Annual Meeting of the Swiss Physiological Society, Fribourg. 2008

M. Fanchaouy, C. Jung, J. Ogrodnik, E. Polakova, N. Shirokova, E.Niggli. Abnormal stress-induced Ca2+ influx into dystrophic MDX cardiomyocytes: involved pathways. 7th Swiss Meeting on Muscle Research, Magglingen, Switzerland. 2008

M. Fanchaouy, E. Polakova, C. Jung, J. Ogrodnik, N. Shirokova, E. Niggli. Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes. Poster. Day of Clinical Research, University Hospital, Bern. 2008

K. Gusev, A.A. Domenigetti, T. Pedrazzini, E. Niggli, M. Egger. Adaptive and maladaptive remodeling of EC-coupling induced by AT-II. Gordon Research Conference "Cardiac Regulatory Mechanisms”, New London, NH, USA. 2008

K. Gusev, A.A. Domenigetti, T. Pedrazzini, E. Niggli, M. Egger. Adaptive and maladaptive remodeling of EC-coupling induced by AT-II. 14th Cardiovascular and Clinical Implication Meeting. Muntelier. 2008

K. Gusev, A.A. Domenigetti, T. Pedrazzini, E. Niggli, M. Egger. M. Remodling of EC-Coupling in hypertrophied cardiomyocytes induced by Chronic AT-II stimulation. 6th Center for Heart Failure Research Symposium, Oslo, Norway. 2008

A.S. Martins, V.M. Shkryl, N.D. Ullrich, M.C. Nowycky, E. Niggli, N. Shirokova. Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibres. Gordon Research Conference "Cardiac Regulatory Mechanisms”, New London, NH, USA. 2008

A. Martins, V.M. Shkyl, N.D. Ullrich, M. Nowycky, E. Niggli, N. Shirokova. Reciprocal amplification of ROS and Ca2+ signals in stressed MDX dystrophic skeletal muscle fibres Poster, 7th Swiss Meeting on Muscle Research, Magglingen, Switzerland. 2008

E. Niggli. RyR Ca2+ sensitivity: Role in in EC-coupling and arrhythmogenesis. Keynote lecture. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. 2008

E. Niggli. Altered Ca2+ signaling and EC-coupling in dystrophic cardiomyopathy. Invited speaker, 6th Center for Heart Failure Research Symposium, Oslo, Norway. 2008

E. Niggli. Hypersensitive EC-coupling and Ca2+ signaling in MDX cardiomyocytes. Lecture, 7th Swiss Meeting on Muscle Research, Magglingen, Switzerland. 2008

J. Ogrodnik, E. Niggli. Altered ryanodine receptor sensitivity after β-adrenergic stimulation of guinea-pig ventricular myocytes. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. 2008

J. Ogrodnik, E. Niggli. Altered ryanodine receptor sensitivity after β-adrenergic stimulation of guinea-pig ventricular myocytes. USGEB meeting Lausanne. 2008

F. Swift, N. Tovsurd, I. Sjaastad, E. Niggli, O.M. Sejersted, M. Egger. Blockade of Na+/K+-ATPase α2-isoform reduces the rate of Ca2+ extrusion through the Na+/Ca2+ exchanger. 6th Center for Heart Failure Research Symposium, Oslo, Norway. 2008

N.D. Ullrich, J. Fanchaouy, K. Gusev, E. Polakova, N. Shirokova, E. Niggli. Changes of EC-coupling and RyR Ca2+ sensitivity in dystrophic mdx mouse cardiomyocytes. Poster. Day of Clinical Research, University Hospital, Bern. 2008

N.D. Ullrich, M. Fanchaouy, K. Gusev, E. Polakova, N. Shirokova, E. Niggli . Changes of EC-coupling and RyR Ca2+ sensitivity in dystrophic mdx mouse cardiomyocytes. Poster at the Gordon Research Conference. 2008

N. Ullrich, M. Fanchaouy, K. Gusev, E. Polakova, N. Shirokova, E. Niggli. Changes of EC-coupling and RyR Ca2+ sensitivity in dystrophic mdx mouse cardiomyocytes. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. Eur J Pharm Biopharm, 2008

N. Ullrich, M. Fanchaouy, K. Gusev, e. Polakova, N. Shirokova, E. Niggli. Changes of EC-coupling and RyR Ca2+ sensitivity in dystrophic mdx mouse cardiomyocytes. Gordon Research Conference "Cardiac Regulatory Mechanisms”, New London, NH, USA. 2008

N.D. Ullrich, M. Fanchaouy, K. Gusev, E. Polakova, N. Shirokova, E. Niggli. Changes of EC-coupling and RyR Ca2+ sensitivity in dystrophic mdx mouse cardiomyocytes. Annual Meeting of the Swiss Physiological Society, Fribourg, Switzerland. Asher-Hess prize for best oral presentation. 2008

N.D. Ullrich, M. Fanchaouy, K. Gusev, E. Polakova, N. Shirokova, E. Niggli. Disruption of the cytoskeletal dystrophin complex alters excitation-contraction coupling mechanisms in cardiomyocytes of the MDX mouse. Poster, 7th Swiss Meeting on Muscle Research, Magglingen, Switzerland. 2008

M. Egger, K. Gusev, A.A. Domenighetti, T. Pedrazzini, E. Niggli. Remodeling of Ca2+signaling in cardiomyocytes in response to chronic cardiac specific angiotensin-II stimulation. Biophys. J. 92:(2007) 352a, 2007

M. Fanchaouy, J. Ogrodnik, E. Niggli. Ca2+ signaling and Ca2+-induced Ca2+ release in dystrophic cardiomyocytes from mdx mice. Annual meeting of the European Society of Cardiology Working Group of Cardiac Cellular Electrophysiology (EWGCCE), Manchester, UK. 2007

K. Gusev, E. Niggli. Blocking countercharge movements into the SR does not affect Ca2+signaling in cardiomyocytes in response to chronic cardiac specific angiotensin-II stimulation. Biophys. J. 92:(2007) 351a, 2007

K. Gusev, E. Niggli. Blocking countercharge movements into the SR does not affect Ca2+ sparks. Biophys. J. 92:138a, 2007

K. Gusev, E. Niggli. Blocking countercharge movememtns into the SR via K+ and Cl- channels does not affect Ca2+ sparks. Gordon conference on Ca2+ signaling, Tilton NH. 2007

C. Jung, E. Niggli, N. Shirokova. Amplification of cellular damage by Ca2+signaling and ROS generating pathways in dystrophic cardiomyopathy. Biophys. J. 92:(2007) 255a, 2007

C. Jung, E. Niggli, N. Shirokova. Abnormal stretch sensitivity in cardiomyocytes from mdx mice. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. 2007

E. Niggli. Ca2+waves, Ca2+diffusion and the sarcoplasmic reticulum. Biophys. J. 92:(2007) 170a, 2007

E. Niggli. RyR Ca2+ sensitivity and its regulation by luminal SR Ca2+: role in stability and arrhythmogenesis? Invited speaker, International symposium on calcium channels and transporters, Manchester, UK. 2007

E. Niggli. Fluorescent calcium indicators and confocal microscopy. Course on confocal microscopy. Swiss Cardiovascular Research and Training Network, Bern, Switzerland. 2007

E. Niggli, C. Jung, N. Shirokova. Amplification of cellular damage by Ca2+ signaling and ROS generating pathways in dystrophic cardiomyopathy. Invited speaker, 2nd international Conference on Muscle Research, Basel 2007, Switzerland. 2007

J. Ogrodnik, E. Niggli. Altered Ryanodine Receptor Sensitivity After β-Adrenergic Stimulation of Guinea-Pig Ventricular Myocytes. Annual meeting of the European Society of Cardiology Working Group of Cardiac Cellular Electrophysiology (EWGCCE), Manchester, UK. 2007

N. Ullrich, K. Gusev, E. Niggli. Disruption of the cytoskeletal dystrophin complex alters excitation-contraction coupling mechanisms in cardiomyocytes of the mdx mouse. Annual meeting of the European Society of Cardiology Working Group of Cardiac Cellular Electrophysiology (EWGCCE), Manchester, UK. 2007

N. Ullrich, K. Gusev, E. Niggli. Disruption of the cytoskeletal dystrophin complex alters excitation-contraction coupling mechanisms in cardiomyocytes of the mdx: mouse. Poster. Day of Clinical Research, University Hospital, Bern. 2007

N.D. Ullrich, K. Gusev, E. Niggli. . Disruption of the cytoskeletal dystrophin complex alters Ca2+ sensing mechanisms in cardiomyocytes of the mdx mouse. Poster at the EWGCCE meeting. 2007

S. Driamov, C. Jung, N. Shirokova, E. Niggli. Abnormal stress sensitivity of dystrophic cardiac myocytes. 12th Cardiovascular Biology and Clinical Implications Meeting, Muntelier, Switzerland. 2006

M. Egger, J. Ogrodnik, G.C.R. Ellis-Davies, E. Niggli. Sub-cellular photorelease of InsP3 in living cells induced by two-photon excitation. Biophys. J. 90:(2006) 322a, 2006

M. Egger, J. Ogrodnik, G.C.R. Ellis-Davis, E. Niggli. Sub-cellular photorelease of InsP3 in living cells induced by two-photon excitation. Gordon Research Conference on Regulation of Cardiac Muscle, New London, USA. 2006

M. Egger, M. Keller, J.P.Y. Kao, E. Niggli. Cellular Ca2+waves are travelling as sensitization wavefronts. Pflugers Arch. 451:(2006) 74, 2006

K Gusev, G. Ackermann, C. Heizmann, E. Niggli. β-adrenergic stimulation reveals phenotype of S100A knock-out in mouse cardiomyocytes. Pflugers Arch. 451:(2006) 136, 2006

K. Gusev, G. Ackermann, C.W. Heizmann, E. Niggli. Ca2+ signaling in S100A1 knock-out mouse cardiomyocytes. Biophys. J. 90:(2006) 72a, 2006

K. Gusev, G. Ackermann, C.W. Heizmann, E. Niggli. Ca2+ Signaling in S100A1 knock-out mouse cardiomyocytes. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. 2006

C. Jung, E. Niggli. Termination of Ca2+release is suppressed by fast Ca2+-buffers in cardiomyocytes. J. Muscle Res. Cell Motil. 27:(2006) 522, 2006

C. Jung, E. Niggli. CICR Inactivation in cardiomyocytes suppressed by fast Ca2+-buffers. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. 2006

C. Jung, E. Niggli. CICR Inactivation in cardiomyocytes suppressed by fast Ca2+-buffers. Gordon Research Conference on Muscle, Excitation-Contraction Coupling, New London, USA. 2006

C. Jung, E. Niggli, N. Shirokova. Abnormal stretch sensitivity in cardiomyocytes from mdx mice. Poster, Gordon Research Conference on Muscle, Excitation-Contraction Coupling, New London, USA. 2006

C. Jung, E. Niggli, N. Shirokova. Abnormal stretch sensitivity in cardiomyocytes from mdx mice. Poster, 6th Swiss Meeting on Muscle Research, Magglingen, Switzerland. 2006

C. Jung, E. Niggli. . CICR inactivation in cardiomyocytes suppressed by fast Ca2+-buffers. Biophys. J. 90:(2006) 71a, 2006

C. Jung, N. Shirokova, E. Niggli. Abnormal stretch sensitivity in cardiomyocytes isolated from dystrophic mdx mice. Annual Meeting of the Swiss Physiological Society, Fribourg, Switzerland. 2006

C. Jung, N. Shirokova, E. Niggli. Abnormal stretch sensitivity in cardiomyocytes isolated from dystrophic mdx mice. Poster. Day of Clinical Research, University Hospital, Bern. 2006

M. Keller, B. Vacher, C. Pignier, M. Egger, E. Niggli. A novel hormone-like compound exerting positive inotropic effects in cardiac muscle. Annual meeting of the Swiss Cardiovascular Research and Training Network, Bern. 2006

M. Keller, J.P.Y. Kao, M. Egger, E. Niggli. Ca2+-waves driven by RyR2 sensitization. Biophys. J. 90:(2006) 322a, 2006

M. Keller, J.P.Y. Kao, M. Egger, E. Niggli. Ca2+-waves driven by RyR sensitization wave fronts. Poster, Gordon Research Conference on Muscle, Excitation-Contraction Coupling, New London, USA. 2006

E. Niggli. Basic mechanisms of excitation/contraction coupling. J. Mol. Cell. Cardiol. 40:(2006) 923, 2006

E. Niggli. Confocal calcium imaging and two-photon photolyis of caged compounds. MIC meeting, Bern, Switzerland. 2006

E. Niggli. Activation and termination of Ca2+-induced Ca2+ release in cardiac muscle. Invited speaker, Northern Cardiovascular Meeting, Leeds, UK. 2006

E. Niggli. Activation and termination of Ca2+-induced Ca2+ release in cardiac muscle. Invited speaker. 41st Congress of the Brazilian Physiological Society, Sao Paulo / Ribeirao Preto, Brazil. 2006

E. Niggli. Abnormal Ca2+ signaling in dystrophic skeletal and cardiac muscle. 6th Swiss Meeting on Muscle Research, Magglingen, Switzerland. 2006

J. Ogrodnik, E. Niggli. Enhanced SR Ca2+ release after ß-adrenergic stimulation in guinea-pig ventricular myocytes attributed to PKA-mediated phosphorylation. Biophys. J. 90:(2006) 71a, 2006

J. Ogrodnik, E. Niggli. Enhanced SR Ca2+ release after β-Adrenergic stimulation in guinea-pig ventricular myocytes attributed to PKA-mediated phosphorylation. Annual meeting of the Swiss Cardiovascular Research and Training Network Bern. 2006

J. Ogrodnik, E. Niggli. Enhanced SR Ca2+ release after β-Adrenergic stimulation in guinea-pig ventricular myocytes attributed to PKA-mediated phosphorylation. Gordon Research Conference on Muscle, Excitation-Contraction Coupling, New London, USA. 2006

J. Ogrodnik, E. Niggli. Enhanced SR Ca2+ release after β-adrenergic stimulation in guinea-pig ventricular myocytes attributed to PKA-mediated phosphorylation. 28th Meeting of the European Working Group on Cardiac Cellular Electrophysiology (EWGCCE) meeting in Florence, Italy. 2006

J. Ogrodnik, E. Niggli. PKA-mediated stimulation of localized SR Ca2+ release in guinea-pig ventricular myocytes. Annual Meeting of the Swiss Physiological Society, Fribourg, Switzerland. 2006

V.M. Shkryl, A.S. Martins, C. Jung, E. Niggli, N. Shirokova. ROS dependent mechanisms contribute to stress induced Ca2+ sparks in muscle. Poster, 6th Swiss Meeting on Muscle Research, Magglingen, Switzerland. 2006

		ao. Professor
	phone:	`++41 31 631 8730`
	Fax:	`++41 31 631 4611`
	E-Mail:	niggli@pyl.unibe.ch
	office:	147d
	Links:	My group

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Prof. Dr.med. Ernst Niggli

Curriculum vitae

Education and professional experience

Teaching Experience

Editorial boards, boards, honors

Memberships in Professional Organizations

Research interests

Research interests

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Publications

Abstracts

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Events