Publications Cardiac calcium signaling group
The yin and yang of intracellular delivery of amphipathic optical probes using n-butyl charge masking. Chem. Commun. 2022 DOI
on the list of Chemical Communications HOT Articles 2022
Uptake-leak balance of SR Ca2+ determines arrhythmogenic potential of RyR2R420Q+/− cardiomyocytes. J. Mol. Cell. Cardiol. 170:1-14, 2022 DOI pdf
Impaired Binding to Junctophilin2 and Nanostructural Alteration in CPVT Mutation. Circ. Res. 2021 DOI
Perspectives from
S. Hamilton, D. Terentyev. RyR2 Gain-of-Function and Not So Sudden Cardiac Death. Circ. Res.
129:417–419, 2021 DOI
Local recovery of cardiac calcium-induced calcium release interrogated by ultra-effective, two-photon uncaging of calcium. J. Physiol. 2021 DOI
Activation of endogenous protein phosphatase 1 enhances the calcium sensitivity of the ryanodine receptor type 2 in murine ventricular cardiomyocytes. J. Physiol. 2020 DOI
Perspectives from
M.L. Munro and P.P. Jones. Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. J. Physiol.
2020 DOI
β-adrenergic receptors in cardiac muscle: it takes two to tango. Cardiovasc. Res. 2020 DOI
Simultaneous Recording of Subcellular Ca2+ Signals from the Cytosol and Sarco/Endoplasmic Reticulum: Compartmentalized Dye Loading, Imaging, and Analysis in Claus W. Heizmann (ed.), Calcium-Binding Proteins of the EF-Hand Superfamily: From Basics to Medical Applications, Methods in Molecular Biology, Springer Cham 1929:53-71, 2019 DOI
Automatic Detection and Classification of Ca2+ Release Events in Confocal Line- and Frame-scan Images. Biophys. J. 2018 DOI
Caged Compounds: Applications in Cardiac Muscle Research in Microscopy of the heart, Springer 75-95, 2018 DOI
Duchenne muscular dystrophy: emerging pathological role for cardiac myopathy. Cardiology: from science to practice 4(33):27-40, 2018 DOI
Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response. J. Gen. Physiol. online, 2018 DOI
Reassessment of the transport mechanism of the human zinc transporter SLC39A2. Biochemistry online, 2018 DOI
Stabilization of Ca2+ signaling in cardiac muscle by stimulation of SERCA. J. Mol. Cell. Cardiol. online, 2018 DOI
Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. BMC Complementary and Alternative Medicine 17:117, 2017 DOI pdf
Calcium Uncaging with Visible Light. J Am Chem Soc 138:3687–3693, 2016 DOI
Real-time intra-store confocal Ca2+ imaging in isolated mouse cardiomyocytes. Cell Calcium online, 2016 DOI
Dystrophic cardiomyopathy - role of TRPV2 channels in stretch-induced cell damage. Cardiovasc. Res. 2015 DOI
IP3 and Ca2+ signals in the heart: boost them or bust them?. J. Physiol. (Lond). 593.6:1385–1386, 2015 DOI
Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes. J. Physiol. 593.6:1495–1507, 2015 DOI
Oxidative Stress and Ca2+ Release Events in Mouse Cardiomyocytes. Biophys. J. 107(12), 2815–2827, 2014 DOI
Cardiac Phenotype of Duchenne Muscular Dystrophy: Insights from Cellular Studies. J. Mol. Cell. Cardiol. 58:217–224, 2013 DOI
Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Cardiovasc. Res. 97:666–675, 2013 DOI
NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle. Cardiovasc. Res. 100:392-401, 2013 DOI
Perspectives from
Mei-ling Anne Joiner. NO generation by β-AR stimulation to activate CaMKII. Cardiovasc. Res.
100:352-353, 2013 DOI
Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling. Biochimica et Biophysica Acta 1833:866–875, 2013 DOI
Isolation of Cardiovascular Precursor Cells from the Human Fetal Heart. Tissue Engineering 18:1-2, 2012 DOI
PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J. Mol. Cell. Cardiol. 53: 33-42, 2012 DOI
Alterations of excitation-contraction coupling and excitation coupled Ca2+ entry in human myotubes carrying CAV3 mutations linked to rippling muscle disease. Hum Mut 32:309-317, 2011 DOI
Ca2+ on the move: what is better – fire and forget, or fire–diffuse–fire?. J. Physiol. (Lond). 588.9:1391–1392, 2010 DOI
Functional coupling of α2-isoform Na+/K+-ATPase and Ca2+ extrusion through theNa+/Ca2+-exchanger in cardiomyocytes. Cell Calcium 48:54–60, 2010 DOI
Increased Ca2+ leak and spatiotemporal coherence of Ca2+ release in cardiomyocytes during β-adrenergic stimulation. J. Physiol. (Lond). 588.1:225-242, 2010 DOI
Perspectives from
Wei Wang and Xander H.T. Wehrens. Stress synchronizes calcium release and promotes SR calcium leak. J. Physiol. (Lond).
391-392, 2010 DOI
Altered sarcoplasmic reticulum calcium transport in the presence of the heavymetal chelator TPEN. Elsevier Cell Calcium 46:347-355, 2009 DOI
Angiotensin II mediated adaptive and maladaptive remodeling of cardiomyocyte excitation contraction coupling. Circ. Res. 105:42-50, 2009 DOI
Ca2+ signaling in mouse cardiomyocytes with ablated S100A1 protein. Gen. Physiol. Biophys. 28:371-383, 2009 DOI
E. Sarcoplasmic reticulum ion channels. In: Cardiac electrophysiology: from cell to bedside. 5th edition. Editors: D.P. Zipes, J. Jalife, 65-75. Saunders/Elsevier, Philadelphia. 2009
How to shut down Ca2+-induced Ca2+ release?. J. Physiol. (Lond). 587.21:5003-5004, 2009 DOI
Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes. AJP Heart Physiol 297:H1992-H2003, 2009 DOI
Perspectives from
Thomas R. Shannon. Ryanodine receptor Ca2+ sensitivity and excitation-contraction coupling in muscular dystrophy and heart failure: similar and yet different. AJP Heart Physiol
297:H1965-H1966, 2009 DOI
Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes. Elsevier Cell Calcium 46:114-121, 2009 DOI
Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch. 458:915-928, 2009 DOI
Dystrophic cardiomyopathy: amplification of cellular damage by Ca2+ signalling and reactive oxygen species-generating pathways. Cardiovasc. Res. 77:766-773, 2008
Modulation of the local SR Ca2+ release by intracellular Mg2+ in cardiac myocytes. J. Gen. Physiol. 132:721-730, 2008 DOI
Studies of RyR function in situ. Elsevier Methods-Elsevier 46:183-193, 2008 DOI
A guide to sparkology: The taxonomy of elementary cellular Ca2+ signaling events. Cell Calcium 42:379-387 , 2007 DOI
Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes. Cell Calcium 41:187-194 , 2007
Calcium waves driven by "sensitization" wave-fronts. Cardiovasc. Res. 74:39-45 , 2007
F90927: A new member in the class of cardiactive steroids. Cardiovasc Drug Rev 25:210-220 , 2007
The cardiac sarcoplasmic reticulum filled with Ca2+and surprises. Circ. Res. 100:5-6, 2007
A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle. Br J Pharmacol 147:772-782, 2006
Agonist specific L-type Ca2+-current stimulation in ventricular myocytes by a novel steroid-like compound. Cell Calcium 39: 425-433, 2006
Founder of cardiac cellular electrophysiology: Honouring Silvio Weidmann, 7 April 1921-11 July 2005. J. Physiol. (Lond). 570:431-432, 2006
Synthesis and two-photon photolysis of 6-(ortho-Nitroveratryl)-caged IP3 in living cells. Chembiochem 7:174-180, 2006
The early years of cellular cardiac electrophysiology and Silvio Weidmann (1921-2005). Heart Rhythm 3(3):353-9, 2006
The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods 3:35-40, 2006
Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium 38: 497-505, 2005
Paradoxical SR Ca2+ release in guinea pig cardiac myocytes after ß-adrenergic stimulation revealed by two-photon photolysis of cated Ca2+. J. Physiol. (Lond). 565.3: 801-813, 2005
Rapid turnover of the "functional" Na+-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach.. Cell Calcium 37:233-243, 2005
Applications of multi-photon microscopy in cell physiology. Front. Biosci. 9: 1598-1610, 2004
Mechanisms of Na-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement. J. Membr. Biol. 198:159-175 , 2004
Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circ. Res. 95:807-813 , 2004
Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. IJBC 13:3535-3560 , 2003
Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Circ. Res. 91:323-330, 2002
Involvement of calcium in rhythmic activity induced by disinhibition in cultured spinal cord networks. J. Neurophysiol. 88:1461-1468, 2002
Spatial characteristics of sarcoplasmic reticulum Ca2+release events triggered by L-type Ca2+ current and Na+ current in guinea-pig cardiac myocytes. J. Physiol. (Lond). 542.2:383-393, 2002
Spatiotemporal features of Ca2+ buffering and diffusion in atrial cardiac myocytes with inhibited sarcoplasmic reticulum. Biophys. J. 83:3134:3151, 2002
Application of antisense oligodeoxynucleotides for suppression of Na+ / Ca2+ exchange. Methods Enzymol. 314:454-476, 2000
L-type Ca2+ current as the predominant pathway of Ca2+ entry during INa activation in β-stimulated cardiac myocytes. J. Physiol. (Lond). 527.3:455-466, 2000
Paradoxical block of the Na+ - Ca2+ exchanger by extracellular protons in guinea-pig ventricular myocytes. J. Physiol. (Lond). 523:353-366, 2000
Ca2+ sparks in cardiac muscle: is there life without them?. NIPS 14:129-134, 1999
Calcium signalling in cardiac muscle: refractoriness revealed by coherent activation. Nature Cell Biology 1:323-329, 1999
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. J. Physiol. (Lond). 516:343-352, 1999
Functional expression of the human cardiac Na+/Ca2+ exchanger in Sf9 cells: rapid and specific Ni2+ transport. Cell Calcium 25:9-17, 1999
Localized Intracellular calcium signaling in muscle: calcium sparks and calcium quarks. Annual Reviews of Physiology 61:311-335, 1999
Ni2+ transport by the human Na-Ca exchanger expressed in Sf9 cells. Am. J. Physiol-Cell Physiol. 276:C1184-1192, 1999
Regulatory function of Na-Ca exchange in the heart: milestones and outlook. J. Membr. Biol. 168:107-130, 1999
Two-photon and UV-laser flash photolysis of the new caged Ca2+ compound DMNPE-4. Cell Calcium 25:85-91, 1999
Confocal near-membrane detection of calcium in cardiac myocytes. Cell Calcium 23:269-279, 1998
Fundamental calcium release events revealed by two-photon excitation photolysis of caged calcium in guinea-pig cardiac myocytes. J. Physiol. (Lond). 508:801-809, 1998
A hierarchical concept of cellular and subcellular Ca2+ signalling. Prog Biophys Mol Biol 65:265-296, 1997
Imaging the hierarchical Ca2+ signalling system in HeLa cells. J. Physiol. (Lond). 499:307-314, 1997
Antisense oligonucleotides directed against the Na-Ca exchanger mRNA: promising tools for studies on the cellular and molecular level. Annals of the New York Academy of Sciences 779:93-103, 1996
Confocal microscopic detection of potential-sensitive dyes used to reveal loss of voltage control during patch-clamp experiments. Pflugers Arch. 433:194-199, 1996
Control of action potential propagation by intracellular Ca2+ in cultured rat dorsal root ganglion cells. J. Physiol. (Lond). 490:319-324, 1996
Photolysis of caged compounds characterized by ratiometric confocal microscopy: a new approach to homogeneously control and measure the calcium concentration in cardiac myocytes. Cell Calcium 19:255-266, 1996
Spatially non-uniform Ca2+ signals by reduction of transverse tubules in citrate-loaded guinea-pig ventricular myocytes in culture. J. Physiol. (Lond). 497:589-597, 1996
Subcellular properties of triggered calcium waves in isolated citrate-loaded atrial myocytes characterized by ratiometric confocal microscopy. J. Physiol. (Lond). 497:599-610, 1996
Submicroscopic calcium signals as fundamental events of excitation-contraction coupling in guinea-pig cardiac myocytes. J. Physiol. (Lond). 492:31-38, 1996
Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. J. Physiol. (Lond). 489:319-326, 1995
Specific inhibition of Na-Ca exchange function by antisense oligodeoxynucleotides. FEBS Letters 364:198-202, 1995
Subcellular features of calcium signaling in heart muscle: what do we learn?. Cardiovasc. Res. 29:441-448, 1995
A confocal laser scanning microscope designed for indicators with ultra-violet excitation wavelengths. Am. J. Physiol. 35:C303-C310, 1994
A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths. Am. J. Physiol. 266:C303–10, 1994
Modulation of Ca2+ release in cardiac myocytes: insight from subcellular release patterns revealed by confocal microscopy. Circ. Res. 74:979-990, 1994
Sodium-current induced calcium signals in isolated guinea-pig ventricular myocytes. J. Physiol. (Lond). 474:439-446, 1994
Voltage dependence of Na-Ca exchange conformational currents. Biophys. J. 67:1516-1524, 1994
Activation of Na-Ca exchange current by photolysis of ‘caged calcium’ in guinea-pig ventricular myocytes. Biophys. J. 65:882-891, 1993
Microscopic spiral-waves reveal positive feedback in subcellular calcium signaling. Biophys. J. 65:2272-2276, 1993
Ratiometric confocal Ca-measurements with visible wavelength indicators in cardiac myocytes. Cell Calcium 14:359-372, 1993
Subcellular restricted spaces: Significance for cell signaling and excitation - contraction coupling. J. Muscle Res. Cell Motil. 14:288-291, 1993
Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature 349:621–624, 1991
Photorelease of Ca2+ produces Na-Ca exchange currents and Na-Ca exchange "gating" currents. Ann NY Acad Sci 639:61-70, 1991
Restoring forces in cardiac myocytes. Insight from relaxations induced by photolysis of caged ATP. Biophys. J. 59:1123–1135, 1991
Modulation of ATP-sensitive potassium channel activity by flash-photolysis of "caged-ATP" in rat heart cells. Pflugers Arch. 415:510–512, 1990
Real-time confocal microscopy and calcium measurements in heart muscle cells: towards the development of a fluorescence microscope with high temporal and spatial resolution. Cell Calcium 11:121–130, 1990
Sodium-calcium exchange in excitable cells: fuzzy space. Science 248:283, 1990
Voltage-independent calcium release in heart muscle. Science 250: 565–568, 1990
Effects of general anesthetics on current flow across membranes in guinea pig myocytes. Am. J. Physiol. 256:C273-C281, 1989
Strontium-induced creep currents associated with tonic contractions in cardiac myocytes isolated from guinea-pigs. J. Physiol. (Lond). 414:549-568, 1989
A laser diffraction system with improved sensitivity for long-time measurements of sarcomere dynamics in isolated cardiac myocytes. Pflugers Arch. 411:462-468, 1988
Mechanical parameters determined in dispersed ventricular heart cells. Experientia 43:1150-1153, 1987