Publications Group Niggli

M.C. Franz, J. Pujol-Gimenez, N. Montalbetti, M. Fernandez-Tenorio, T.R. DeGrado, E. Niggli, M.F. Romero and M.A. Hediger.
Reassessment of the transport mechanism of the human zinc transporter SLC39A2. Biochemistry online, 2018 DOI

S. Srimachai, S. Devaux, C. Demougeot, S. Kumphune, N.D. Ullrich, E. Niggli, K. Ingkaninan, N. Kamkaew, C.N. Scholfield, S. Tapechum and K. Chootip.
Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. BMC Complementary and Alternative Medicine 17:117, 2017 DOI pdf

I. Plaisance, S. Perruchoud, M. Fernandez-Tenorio, C. Gonzales, S. Ounzain, P. Ruchat, M. Nemir, E. Niggli, T. Pedrazzini.
Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression. JACC BTS 2016, 2016 DOI pdf

E. Niggli.
IP3 and Ca2+ signals in the heart: boost them or bust them?. J. Physiol. (Lond). 593.6:1385–1386, 2015 DOI

E. Poláková, A. Illaste, E. Niggli, E.A. Sobie.
Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes. J. Physiol. 593.6:1495–1507, 2015 DOI

S. Kyrychenko, E. Polakova, Ch. Kang, K. Pocsai, N.D. Ullrich, E. Niggli, N. Shirokova.
Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Cardiovasc. Res. 97:666–675, 2013 DOI

E. Niggli, N.D.Ullrich, D. Gutierrez, S. Kyrychenko, E. Poláková, N. Shirokova.
Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling. Biochimica et Biophysica Acta 1833:866–875, 2013 DOI

C. Gonzales, N.D. Ullrich, S. Gerber, C. Berthonneche, E. Niggli, T. Pedrazzini.
Isolation of Cardiovascular Precursor Cells from the Human Fetal Heart. Tissue Engineering 18:1-2, 2012 DOI

N.D. Ullrich, D. Fischer, C. Kornblum, M.C. Walter, E. Niggli, F. Zorzato, S. Treves.
Alterations of excitation-contraction coupling and excitation coupled Ca2+ entry in human myotubes carrying CAV3 mutations linked to rippling muscle disease. Hum Mut 32:309-317, 2011 DOI

E. Niggli.
Measuring calcium in ‘fuzzy’ spaces. J. Physiol. (Lond). 589.11:2663, 2011 DOI

E. Niggli.
Ryanodine receptors: waking up from refractoriness. Cardiovasc. Res. 91:563-564, 2011 DOI

E. Niggli.
Ca2+ on the move: what is better – fire and forget, or fire–diffuse–fire?. J. Physiol. (Lond). 588.9:1391–1392, 2010 DOI

F. Swift, N. Tovsruda, I. Sjaastada, O. M. Sejersteda, E. Niggli, M. Egger.
Functional coupling of α2-isoform Na+/K+-ATPase and Ca2+ extrusion through theNa+/Ca2+-exchanger in cardiomyocytes. Cell Calcium 48:54–60, 2010 DOI

M. Sztretye, J. Almassy, T. Deli, P. Szentesi, C. Jung, B. Dienes, C.A. Simut, E. Niggli, I. Jona, L. Csernoch.
Altered sarcoplasmic reticulum calcium transport in the presence of the heavymetal chelator TPEN. Elsevier Cell Calcium 46:347-355, 2009 DOI

K. Gusev, A.A. Domenighetti, L.M.D. Delbridge, T. Pedrazzini, E. Niggli, M. Egger.
Angiotensin II mediated adaptive and maladaptive remodeling of cardiomyocyte excitation contraction coupling. Circ. Res. 105:42-50, 2009 DOI

E. Niggli.
E. Sarcoplasmic reticulum ion channels. In: Cardiac electrophysiology: from cell to bedside. 5th edition. Editors: D.P. Zipes, J. Jalife, 65-75. Saunders/Elsevier, Philadelphia. 2009

E. Niggli.
How to shut down Ca2+-induced Ca2+ release?. J. Physiol. (Lond). 587.21:5003-5004, 2009 DOI

V.M. Shkryl, A.S. Martins, N.D. Ullrich, M.C. Nowycky, E. Niggli, N. Shirokova.
Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch. 458:915-928, 2009 DOI

E. Niggli, N. Shirokova.
A guide to sparkology: The taxonomy of elementary cellular Ca2+ signaling events. Cell Calcium 42:379-387 , 2007 DOI

E. Niggli.
The cardiac sarcoplasmic reticulum filled with Ca2+and surprises. Circ. Res. 100:5-6, 2007

C Pignier, M Keller, B. Vié, B Vacher, M Santelli, E Niggli, M Egger, B Le Grand.
A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle. Br. J. Pharmacol. 147:772-782, 2006

M. Keller, C Pignier, M Santelli, B Vacher, E Niggli, M Egger.
Agonist specific L-type Ca2+-current stimulation in ventricular myocytes by a novel steroid-like compound. Cell Calcium 39: 425-433, 2006

E. Niggli, A G Kléber, R Weingart.
Founder of cardiac cellular electrophysiology: Honouring Silvio Weidmann, 7 April 1921-11 July 2005. J. Physiol. (Lond). 570:431-432, 2006

S Kantevari, C J Hoang, J Ogrodnik, M Egger, E Niggli, G C R Ellis-Davies.
Synthesis and two-photon photolysis of 6-(ortho-Nitroveratryl)-caged IP3 in living cells. Chembiochem 7:174-180, 2006

A.G. Kléber, E. Niggli, J.A.S. McGuigan, R. Weingart.
The early years of cellular cardiac electrophysiology and Silvio Weidmann (1921-2005). Heart Rhythm 3(3):353-9, 2006

A Momotake, N Lindegger, E Niggli, R J Barsotti, G C R Ellis-Davies.
The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods 3:35-40, 2006

M. Egger, H. Porzig, E. Niggli, B. Schwaller..
Rapid turnover of the "functional" Na+-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach.. Cell Calcium 37:233-243, 2005

E. Niggli, M. Egger.
Applications of multi-photon microscopy in cell physiology. Front. Biosci. 9: 1598-1610, 2004

M. Keller, C. Pignier, E. Niggli, M. Egger.
Mechanisms of Na-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement. J. Membr. Biol. 198:159-175 , 2004

H. Zhang, D. Noble, M. Cannell, C. Orchard, M. Lancaster, M.R. Boyett, A.V. Holden, M. Saleet Jafri, E.A. Sobie, W.J. Lederer, S.S. Demir, A. Michailova, F. DelPrincipe, M. Egger, E. Niggli, G.L. Smith, C.M. Loughrey, N. MacQuaide. J. Dempster, A.T. Trafford.
Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. IJBC 13:3535-3560 , 2003

E. Niggli, M. Egger.
Calcium quarks. Front. Biosci. 7:d1288-1297, 2002

A.M. Gómez, B. Schwaller, H. Porzig, G. Vassort, E. Niggli, M. Egger.
Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Circ. Res. 91:323-330, 2002

P. Darbon, C. Pignier, E. Niggli, J. Streit.
Involvement of calcium in rhythmic activity induced by disinhibition in cultured spinal cord networks. J. Neurophysiol. 88:1461-1468, 2002

E. Niggli.
Ca2+ sparks in cardiac muscle: is there life without them?. NIPS 14:129-134, 1999

R. Assandri, M. Egger, M. Gassmann, E. Niggli, C. Bauer, I. Forster, A. Gölach.
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. J. Physiol. (Lond). 516:343-352, 1999

E. Niggli.
Localized Intracellular calcium signaling in muscle: calcium sparks and calcium quarks. Annual Reviews of Physiology 61:311-335, 1999

M. Egger, A. Ruknudin, E. Niggli, W.J. Lederer, D.H. Schulze.
Ni2+ transport by the human Na-Ca exchanger expressed in Sf9 cells. Am. J. Physiol-Cell Physiol. 276:C1184-1192, 1999

M. Bootman, E. Niggli, M. Berridge, P. Lipp.
Imaging the hierarchical Ca2+ signalling system in HeLa cells. J. Physiol. (Lond). 499:307-314, 1997

E. Niggli, B. Schwaller, P. Lipp.
Antisense oligonucleotides directed against the Na-Ca exchanger mRNA: promising tools for studies on the cellular and molecular level. Annals of the New York Academy of Sciences 779:93-103, 1996

A.W. Trafford, P. Lipp, S.C. O’Neill, E. Niggli, D.A. Eisner.
Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. J. Physiol. (Lond). 489:319-326, 1995

E. Niggli, P. Lipp.
Subcellular features of calcium signaling in heart muscle: what do we learn?. Cardiovasc. Res. 29:441-448, 1995

E. Niggli, D.W. Piston, M.S. Kirby, H. Cheng, D.R. Sandison, W.W. Webb, W.J. Lederer.
A confocal laser scanning microscope designed for indicators with ultra-violet excitation wavelengths. Am. J. Physiol. 35:C303-C310, 1994

E. Niggli, D.W. Piston, et al.
A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths. Am. J. Physiol. 266:C303–10, 1994

E. Niggli, P. Lipp.
Voltage dependence of Na-Ca exchange conformational currents. Biophys. J. 67:1516-1524, 1994

E. Niggli, W.J. Lederer.
Activation of Na-Ca exchange current by photolysis of ‘caged calcium’ in guinea-pig ventricular myocytes. Biophys. J. 65:882-891, 1993

E. Niggli, P. Lipp.
Subcellular restricted spaces: Significance for cell signaling and excitation - contraction coupling. J. Muscle Res. Cell Motil. 14:288-291, 1993

E. Niggli, W.J. Lederer.
Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature 349:621–624, 1991

E. Niggli, W.J. Lederer.
Photorelease of Ca2+ produces Na-Ca exchange currents and Na-Ca exchange "gating" currents. Ann NY Acad Sci 639:61-70, 1991

E. Niggli, W.J. Lederer.
Restoring forces in cardiac myocytes. Insight from relaxations induced by photolysis of caged ATP. Biophys. J. 59:1123–1135, 1991

E. Niggli, W.J. Lederer.
Real-time confocal microscopy and calcium measurements in heart muscle cells: towards the development of a fluorescence microscope with high temporal and spatial resolution. Cell Calcium 11:121–130, 1990

E. Niggli, W.J. Lederer.
Voltage-independent calcium release in heart muscle. Science 250: 565–568, 1990

E. Niggli, A. Rüdisüli, P. Maurer, R. Weingart.
Effects of general anesthetics on current flow across membranes in guinea pig myocytes. Am. J. Physiol. 256:C273-C281, 1989

E. Niggli.
Strontium-induced creep currents associated with tonic contractions in cardiac myocytes isolated from guinea-pigs. J. Physiol. (Lond). 414:549-568, 1989

E. Niggli.
A laser diffraction system with improved sensitivity for long-time measurements of sarcomere dynamics in isolated cardiac myocytes. Pflugers Arch. 411:462-468, 1988

E. Niggli.
Mechanical parameters determined in dispersed ventricular heart cells. Experientia 43:1150-1153, 1987